Muna ba da 5-Azacytidine API

Muna alfaharin bayarwa 5-Azacytidine API, wani babban ingancin magani da ake amfani dashi azaman maganin antineoplastic da antiviral. Ana amfani da wannan API da farko a cikin maganin cutar sankarar jini na myeloid mai tsanani, tsarin myelodysplastic, da cutar sankarar myelomonocytic na al'ada. An ƙera samfurin mu bisa ingantattun ka'idoji masu inganci, ƙaƙƙarfan ƙazanta da ingancin sa. Ana samunsa cikin girman marufi masu launuka don dacewa da takamaiman yanayin ku. Amince da mu don ba ku da wani abin dogaro da ingantaccen ƙarfi na 5-Azacytidine. tuntuɓar mu lokaci don ƙarin koyo game da wannan samfurin da kuma yadda za mu iya taimaka muku.

Menene Azacytidine?

5- Azacytidine foda, wanda kuma aka sani da Azacitidine ko 5- AC, wani sinadari ne. Analog ne na nucleoside wanda aka yi da gindin adenine da faci mai sifar zobe da aka zabo wani keken keke na nitrogen wanda ya ƙunshi nitrogen. Yana da DNA methyltransferase kadara kuma ana amfani dashi akai-akai don magance tsarin myelodysplastic (MDS), yanayin jini. Sunan sinadarai shine 4- Amino- 1- (- D- ribofuranosyl) (1H) - daya, kuma lambar CAS shine. 320-67-2. Tsarin sinadaransa shine C8H12N4O5, kuma nauyin kwayoyinsa shine 244.2 g/ spook. Yana iya canza maganganun kwayoyin halitta kuma yana da fa'idodin gyarawa a cikin yanayi kamar tsarin myelodysplastic (MDS) ta hanyar snooping tare da tsarin methylation na DNA. Ta hanyar hana canje-canjen methylation na DNA, yana haɓaka haɓakar ƙwayoyin hematopoietic lafiya kuma yana juyar da daidaituwar ƙwayoyin hematopoietic mara kyau.

Binciken 5-Azacytidine ya samo asali ne tun a shekarun 1950. Ana iya samun taƙaitaccen binciken bincikensa a nan:

Na farko Azacytidine API An gudanar da rikice-rikice a cikin 1958 ta hanyar masu gwaji daga Sashen Ci gaban Sinadarai na Cibiyoyin Lafiya na Ƙasa a Amurka. Sun kafa cewa wannan abu ya hana methylation na DNA ta salula.

Cibiyar Ciwon daji ta kasa (NCI) a Amurka ta fara gudanar da sabon bincike a kan azacytidine a 1964.

Azacitidine foda sun wuce sabon bincike da haɓaka a cikin shekarun da suka gabata. Hukumar Abinci da Magunguna ta Amurka (FDA) ta ba Azacytidine (kuma ana siyar da shi azaman Vidaza) albarka a cikin 1985 don aiwatar da ƙirar myelodysplastic mai girma (MDS). A sakamakon haka, an yi amfani da shi akai-akai don kula da MDS kuma.

Basic Bayani

Sunan samfur: 5-Azacytidine
CAS:320-67-2
Saukewa: C8H12N4O5
MW: 244.2
EINECS: 206-280-2
MDL Lamba: MFCD00006539
Tsafta: 99%
Kwanciyar hankali: Barga don shekaru 2
solubility: Mai narkewa a cikin DMSO (har zuwa 25 mg / ml), ko cikin Ruwa (har zuwa 12 mg / ml).
Aikace-aikace: Matsayin magani ko amfani dashi don bincike.
Shiryawa: Kamar yadda kuke bukata
Adana: Yanayin ɗaki.
Tsarin tsari:

Matsayin narkewa: 226 zuwa 232 ℃

Tushen tafasa: 534.5 ℃

Ruwa mai narkewa: mai narkewa

Girma: 2.08 g/cm ³

Matsakaicin walƙiya: 277 ℃

quality misali

Shiryawa: 500g/bag; 1kg/bag

Yanayin ajiya: -20 ℃, tabbacin danshi, hatimi, da tabbacin haske

Yanayin sufuri: 2-8 ℃ sufuri

Category: Abubuwa masu guba

Rarraba guba: mai guba sosai

Mummunan guba: Oral LD50 a cikin mice: 572 mg / kg; Mouse na ciki LD50: 68 mg/kg

Halayen haɗari na flammability: flammable; Konewa yana haifar da hayaki mai guba na nitrogen oxide; Illolin magani ga marasa lafiya: tashin zuciya, amai, gudawa, da raguwar fararen jini

Mai kashewa: busassun foda, kumfa, yashi, carbon dioxide, ruwa mai atomized

Mene ne aikace-aikace na 5-Azacytidine foda ?

Wadannan su ne manyan amfani da su 5-Azacytidine foda da yankunan aikace-aikacensa:

1. Magungunan Antimetabolic

Babban alamar cutar sankarar bargo ta myeloid mai tsanani wacce ba ta da tasiri a kan jiyya ta al'ada. Ana kuma amfani da ita don ciwon nono, melanoma, ciwon hanji, da dai sauransu. Babban bayyanar da guba shine leukopenia, thrombocytopenia, da anemia. Tashin zuciya da amai sune halayen da ba su dace ba, waɗanda za'a iya inganta su ta hanyar jiko mai tsawo ko ta amfani da maganin hana kumburi sa'o'i 24 zuwa 48 kafin magani. Sauran illa masu guba sun haɗa da gudawa, cututtukan neuromuscular, zazzabi, hauhawar jini, da kurji. An shirya samfurin sabo ne 3-4 hours kafin amfani.

2.A m girma mai hanawa da cytotoxic wakili

Hanawa na DNChemicalbookA methyltransferase, muhimmin tsari na tsari don maganganun kwayoyin halitta, kunnawa, da shiru; Masu hana ciwon daji tare da raunin aikin antibody (Gram positive); An yi amfani da shi don nazarin tasirin ƙwayoyin haɗin gwiwar DNA yayin aiwatar da DNA methylation

3. Mai yuwuwar haɓakar haɓakar haɓakar ƙwayar cuta da mai ɗaukar cytotoxic

Hana DNA methyltransferase, wanda shine muhimmin tsari na tsari don bayyana kwayoyin halitta, kunna kwayoyin halitta, da kuma kashe kwayoyin halitta. Wannan abu yana haifar da demethylation na DNA ko rabin demethylation, yana barin abubuwan da aka rubuta su ɗaure ga DNA da sake kunna ƙwayoyin cuta masu hana ƙari.

Bayanan tsaro

Alamar kayayyaki masu haɗari: T

Lambar nau'in haɗari: 45-46-22

Safety instructions: 53-22-36/37/39-45

WGK Jamus: 3

Lambar RTECS: XZ3017500

F: 10-23

Lambar kwastam: 29349990

Bayanan Abubuwan Guba: 320-67-2

Mai guba: LD50 a cikin mice (mg/kg): 115.9 ip; 572.3 Baka (Palm, Kensler)

Dokar Pharmacological

Azacytidine yana yin tasirin anti-tumor ta hanyar rage DNA methylation da kuma yin amfani da cytotoxicity kai tsaye a kan kasusuwan kasusuwa mara kyau na hematopoietic. Nazarin in vitro ya nuna cewa tattarawar wannan samfur a iyakar hana DNA methylation baya hana haɗin DNA da muhimmanci. Abubuwan da ke faruwa na ƙananan methylation na iya mayar da aikin al'ada na kwayoyin halitta da ke da alaka da bambance-bambance da yaduwar litattafan sinadarai masu kyau. Tasirin cytotoxic na wannan samfur na iya haifar da mutuwar ƙwayoyin da ke yaɗuwa cikin sauri, gami da ƙwayoyin kansa waɗanda suka rasa ikon sarrafa na'ura na yau da kullun, yayin da ƙwayoyin da ba su yaɗuwa ba su da ƙarancin kulawa ga wannan samfurin. Bayani, Properties na physicochemical, hanyoyin shirye-shirye, tasirin magunguna, da aikace-aikacen azacitidine

Our Riba

Kwarewar wadata: muna da Shekaru 13 na ƙwarewar ƙwararru;

Abokan ciniki a duk faɗin duniya: sayar da su zuwa ƙasashe fiye da 100;

Samar da samfuran iri-iri: samfuran an yi amfani da su ga duk manyan samfuran duniya a fagen magunguna, abubuwan abinci, kayan kwalliya, abinci mai gina jiki na dabba da abinci mai aiki.

Farashin farashi: ƙananan MOQ tare da farashin gasa;

Takaddun shaida mai inganci: ISO; Halal; Kosher bokan

Sabis na tallace-tallace: Ƙwararrun ƙungiyar 7 * 24 hours sabis na abokin ciniki.

A taƙaice, a matsayin kwararre Azacitidine API masana'anta, muna da fasahar ci gaba, fa'idar sikelin, mafi kyawun inganci, ƙwarewar samarwa mai wadata, da kyawawan ayyuka. Waɗannan fa'idodin za su sa ya fice a gasar kasuwa kuma ya sami ƙarin amincewa da goyan bayan abokin ciniki.

bayanin tuntuɓar mu: 

Imel:sales@yihuipharm.com
Tel: 0086-29-89695240
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