Menene Acitretin API?

API ɗin Acitretin, wani magani ne da aka yi daga bitamin A, wanda kuma aka sani da all-trans retinoic acid ko betarretin A. Yana sarrafa yawancin ƙwayoyin fata da ke yaduwa da bambanta yayin da yake shafar yadda stratum corneum ke tasowa. Yana inganta cututtuka kamar keratosis, yana rage kuraje, kuma yana sarrafa launin fata ta hanyar haɗawa da mai karɓar bitamin A acid a cikin tsakiya na sel da canza fassarar kwayar halitta da bayanin furotin. Tare da nauyin kwayoyin halitta na 326.43 g / mol da tsarin sinadarai na C21H26O3, Sau da yawa yana ɗaukar nau'in crystal mai launin rawaya ko foda. Yana da lambar CAS 55079-83-9. Ana iya amfani da Hexane don ƙarfafa shi, kuma wurin narkewa shine 228 - 230 ° C. LD50 ta allurar intraperitoneal ta jeri daga> 4000 mg/kg (rana 1) zuwa 700 mg/kg(kwanaki 10 da kwanaki 20), bisa ga bincike kan m guba a cikin mice. Metabolite mai aiki na tretinoin shine acitretin, takwaransa mai zaki na roba na bitamin A. Baya ga sauran yanayin fata, ana amfani da shi don magance psoriasis mai tsanani da keratosis.

Basic Bayani 

Sunan samfurin: Acitretin

CAS: 55079-83-9

Saukewa: C21H26O3

MW: 326.43

EINECS: 259-474-4

MDL Lamba: MFCD00866632

Matsayin narkewa: 228-230°C

Tushen tafasa: 404.46°C (ƙididdigar ƙima)

Maɗaukaki 1.1348 (ƙididdigar ƙima)

Indexididdigar refractive 1.4700 (ƙididdiga)

yanayin ajiya. -20°C

Kwanciyar hankali: Barga

Tsarin tsari:

quality misali 

Aiki & Aikace-aikace

API ɗin Acitretin magani ne na baka na rukunin magunguna na retinoid. Ana amfani da shi da farko don kula da yanayin fata daban-daban, musamman psoriasis mai tsanani (zazzaɓin plaque psoriasis), cututtukan keratinization, da palmoplantar keratoderma.

Mai zuwa shine jerin aikace-aikacen sa da ayyuka:

• Maganin Psoriasis: yana rage ƙaiƙayi, ƙwanƙwasa, jajayen tabo, da ciwon haɗin gwiwa da ke hade da psoriasis. Yana sarrafa rabon salula da yaduwa, wanda ke rage yawan keratinization da kumburi da kuma rage tsananin cutar psoriasis.

• Jiyya na keratinization cuta: ana iya amfani dashi don bi da loricrin keratoderma da wadanda ba epidermolytic palmoplantar keratoderma. Ana inganta bayyanar cututtuka da kamannin fata ta hanyar rage yawan keratinization na fata.

• Jiyya na palmoplantar keratoderma: yana iya bi da palmoplantar keratoderma ta hanyar rage kauri da matakin keratinization a cikin tafin hannu da tafin hannu, yana rage alamun bayyanar cututtuka irin su ciwo, fissures, da kuma ƙara keratinization.

Yana iya haifar da illa a lokacin jiyya, irin su bushe baki, cheilitis, alamun ido, da canza aikin hanta, don haka yana da mahimmanci a san wannan. A sakamakon haka, ya kamata a yi amfani da shi a ƙarƙashin kulawar likita, tare da ci gaba da kimanta ingancinsa da amincinsa. Har ila yau, ba a ba da shawarar amfani da mata masu ciki ko masu shayarwa ba saboda yana iya cutar da tayin ko jarirai.

Halin halayen halayen

Busassun lebe, cheilitis, stomatitis angular, busassun mucosa na baki ko bushewa, da epithelium na tsaka-tsaki sune alamun manyan matakan bitamin A. Rashin haƙuri ga ruwan tabarau, keratitis, ulceration na corneal, da conjunctivitis. alamun kumburin hanji. kishirwa da gumi. asarar gashi wanda ke juyawa. fatar da ta fi sirara da gyale. Paronychia, haɓakar ƙusa da ba a saba gani ba, granuloma, da kwarangwal na lokaci-lokaci, haɗin gwiwa, da ciwon tsoka. rage high-yawa lipoprotein, ƙara triglycerides da cholesterol, high transaminases da alkaline phosphatase. Ƙara yawan alamun matsa lamba na ciki sun haɗa da ciwon kai, hangen nesa, ƙima mai yawa, ƙididdiga mai yawa, osteoporosis, da farkon rufewar farantin epiphyseal.

Hanyar samarwa

4-methoxy-2,3,6-trimethylbenzaldehyde (Ⅰ) da ethyl formate suna amsawa a cikin phosphoric acid mai ɗauke da ethanol don samar da fili (Ⅱ) tare da yawan amfanin ƙasa na 84%. Sannan, yana amsawa da (Ⅲ) a cikin ethyl acetate mai ɗauke da zinc chloride don samar da cakuda 6:4 (E)-(Ⅳ) da (Z)-(Ⅳ), tare da jimlar yawan amfanin ƙasa na 83%. Kashe acid yana bada 27% na (E,E)-(V) da 21% na (Z,E)-(V). (E, E) (V) yana amsawa tare da acetone a cikin maganin methanol-ruwa don samar da 25% na fili (Ⅵ). Yana amsawa tare da ethoxyethynylmagnesium bromide Grignard reagent a cikin ether don samar da fili (Ⅶ) tare da yawan amfanin ƙasa na 48%. A ƙarshe, hydrolysis yana samar da samfurin 91%.

Kwanciyar hankali & ajiya

Ya samo asali ne daga bitamin A acid. Kwanciyarsa da yanayin ajiyarsa sune kamar haka:

Kwanciyar hankali: Yana iya zama ɗan kwanciyar hankali na dogon lokaci lokacin da aka adana shi a bushe, kariyar haske, da yanayin rufewa. Duk da haka, yana da kula da haske kuma yana iya sauƙi ragewa da rasa tasiri lokacin da aka fallasa shi zuwa haske. Har ila yau, yana kula da yanayin zafi da oxygen, wanda zai iya rage kwanciyar hankali.

Yanayin ajiya: Don tabbatar da kwanciyar hankalinsa, ana ba da shawarar yanayin ajiya masu zuwa:

• Zazzabi: Ajiye shi a dakin da zafin jiki (15 ° C - 30 ° C).

• Humidity: Kula da ƙarancin zafi mai ɗanɗano kuma guje wa mahalli mai ɗanɗano.

• Haske: Sanya shi a cikin kwantena masu haske don hana bayyanar haske kai tsaye.

• Marufi: Yi amfani da kwantena da aka rufe ko kayan marufi don tabbatar da hatimin da ya dace.

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a ƙarshe

A taƙaice, a matsayin kwararre API ɗin Acitretin masana'anta, muna da fasahar ci gaba, fa'idar sikelin, mafi kyawun inganci, ƙwarewar samarwa mai wadata, da kyawawan ayyuka. Waɗannan fa'idodin za su sa ya fice a gasar kasuwa kuma ya sami ƙarin amincewa da goyan bayan abokin ciniki. idan kana bukata, pls jin kyauta a tuntube mu kowane lokaci. zamu amsa muku da asap.

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