2-Deoxy-D-glucose foda Supplier

Kamfanin Xi'an Yihui ƙwararrun masana'anta ne na mafi kyau 2-Deoxy-D-glucose foda. Za mu iya samar da 2DG tare da abun ciki na 99.9%. Ana iya amfani da shi a cikin abinci, magani, kayan kiwon lafiya, ko kayan kwalliya kuma ya dace da matsayin USP, BP, EP, CP. Za mu iya ba ku samfuran mafi girman ma'auni a mafi girman farashin farashi. Mafi kyawun zaɓi don ingantaccen mai samar da 2DG shine Kamfanin Xi'an Yihui!

Menene 2-Deoxy-D-glucose foda?

2- Deoxy- D- Glucose foda wani sinadari ne, tsarin sinadaransa shine C6H12O5 kuma nauyin kwayoyinsa shine 164.16 g/ spook, CAS NO. shine 154-17-6. Sigar carbon ce guda shida kwatankwacin glucose, amma rashin ƙungiyar hydroxyl a madadin snippet na carbon, don haka ake kira "deoxy" glucose. Farar demitasse ce mai ƙarancin narkewa a cikin ruwa. 2DG shine mai rushewar rayuwa na asibiti wanda zai iya hana ɗaukar glucose ta salula da aikace-aikace, yana haifar da raguwar yanayin ATP a cikin sel.

Wannan miyagun ƙwayoyi yana aiki ne akan ƙwayoyin ƙari da wasu ƙwayoyin cuta waɗanda ke dogara da sukari a matsayin babban abin da ke haifar da rayuwa. Yin amfani da 2DG zai iya sa waɗannan sel su mutu sosai ko rage girman girman su. Bugu da ƙari, ana amfani da 2DG azaman kayan aiki a cikin ilimin kimiyyar ƙwaƙwalwa da bincike na metabolism saboda yana iya daidaita yanayin gajiyar rayuwa, yana bayyana cikakkun bayanai na hanyoyin rayuwa na salon salula.

Ganowar 2-Deoxy-D-glucose ana iya gano shi tun farkon shekarun 1950. A wancan lokacin, masana kimiyya na Amurka Haskell Smith da Morris Ficher sun gano wani emulsion da ake kira 2-deoxyglucose yayin da suke nazarin hanyoyin daukar glucose ta salula. Daga baya, wani masanin kimiyya Takashi Otsuka ya gano cewa 2-deoxy glucose na iya shiga cikin metabolism na glucose cell kuma ya hana rarraba tantanin halitta yayin rikice-rikicen DNA.

Daga baya, masana kimiyya sun gudanar da ƙarin bincike akan 2-DG foda da kuma kafa cewa zai iya hana ci gaban wasu ƙwayoyin cuta da ƙwayoyin cuta yayin da yake da mafi ƙarancin kaya akan ƙwayoyin al'ada.

Don haɓaka ingancin 2DG, masana kimiyya sun fara ƙira da haɗa motes masu kama da juna. A cikin wannan tsari, sun kafa cewa 2DG ya kasance mafi tasiri mai rushewar rayuwa, yana iya hana ɗaukar glucose ta cell yadda ya kamata. A halin yanzu, 2DG ya zama muhimmin kayan aikin gwaji da magani na asibiti.

Basic Bayani

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Tsarin Magana

Tsarin kira na 2-deoxy-D-glucose fodar ya ƙunshi matakai guda biyu:

A mataki na farko, glucose yana jujjuyawar Knoevenagel ta hanyar amsawa tare da methyl vinyl ketone don samar da α, β-unsaturated carbonyl fili.

A mataki na biyu, tThe unsaturated fili an rage zuwa manufa samfurin 2-deoxy-D-glucose ta hanyar hydrogenation rage.

Anan ga takamaiman matakan amsawa:

Matsakaicin matakin farko:

Glucose + Methyl vinyl ketone → α, β-unsaturated carbonyl fili

Na'urar dauki mataki na farko:

A ƙarƙashin yanayin alkaline, glucose da methyl vinyl ketone suna aiki azaman masu haɓaka nucleophilic kuma suna jurewa Knoevenagel condensation tare da taimakon thioacetone ko sodium hydroxide, suna ba da α, β-unsaturated carbonyl fili.

Daidaiton amsa mataki na biyu:

α, β-unsaturated carbonyl fili + Hydrogen gas + mai kara kuzari → 2-deoxy-D-glucose

Hanyar amsawa mataki na biyu:

A gaban hydrogen gas da mai kara kuzari, the- unsaturated carbonyl emulsion ne hydrogenated don samar da 2-deoxy-D-glucose. Ana amfani da madaidaicin madaidaicin mai kama da platinum ko taka tsantsan don wannan martanin hydrogenation.

Ya kamata a lura cewa salon gama gari ɗaya ne kawai don haɗa 2-deoxy-D- glucose. A gaskiya ma, akwai wasu hanyoyi daban-daban na roba, irin su bitar sinadarai na uracil da ƙananan ƙwayoyin cuta.

wani fili ne mai matukar muhimmanci da ake amfani da shi sosai a fannin likitanci, fasahar kere-kere, da masana’antar abinci. Ga wasu fa'idojinsa:

Ba shi da wani sakamako mai guba a jikin ɗan adam kuma yana da zaɓin kisa akan ƙwayoyin kansa;

Yana da anti-virus, antifungal, anti-diabetes, anti-kiba da sauran tasiri;

Ana iya shanye shi kuma ya daidaita shi ta jikin mutum;

Ana iya amfani da shi azaman reagent mai lakabin rediyo ko wakilin gyaran DNA a cikin fasahar kere-kere;

Ana iya amfani dashi azaman mai zaki mai ƙarancin kalori a cikin masana'antar abinci;

A takaice, mahadi ne mai matukar amfani tare da aikace-aikace iri-iri.

Menene Aiki Na 2 Deoxy Glucose?

2 deoxy glucose (2DG) shine analog na glucose wanda ba shi da rukunin hydroxyl a matsayi na 2 na zoben glucose. Gabaɗaya ana amfani da shi a cikin binciken kimiyya azaman kayan aiki don bincika metabolism na glucose da hanyoyin da ke da alaƙa. Ga wasu ayyukanta:

1. Kadari na glycolysis 2DG ana ɗauka ta hanyar sel ta hanyar masu jigilar glucose da phosphorylated ta hexokinase zuwa 2DG-6-phosphate, wanda ba zai iya zama mai nisa ta hanyar glycolysis ba. don haka, 2DG na iya yin gasa ta hana ɗaukar glucose da glycolysis, wanda shine mataki na farko a cikin metabolism na makamashi.

2. Debaser na autophagy Autophagy shine matsakaicin raguwar salula wanda ke taimakawa wajen kula da homeostasis na salula ta hanyar dawo da lalacewa ko maras so sunadaran da kwayoyin halitta. 2DG yana haifar da autophagy ta hanyar hana manufar mammalian hanyar rapamycin (mTOR), wanda ke haifar da kunna kwayoyin halitta masu alaƙa da autophagy.

3. Radiosensitizer: Kwayoyin ciwon daji suna da karuwar glucose da kuma glycolytic flux fiye da kwayoyin halitta, wanda aka sani da tasirin Warburg. Don haka, 2DG na iya zaɓin wayar da kan ƙwayoyin kansa zuwa maganin rediyo ta hanyar hana glycolysis da haɓaka martanin damuwa na salon salula.

4. Abubuwan gyarawa don yanayin neurodegenerative 2DG an nuna su don inganta aikin fahimi da kuma rage neuropathology a cikin nau'ikan dabbobi na korafin Alzheimer da korafin Parkinson. Wannan na iya tasiri daga haɓaka metabolism na glucose a cikin kwakwalwa, rage kumburin neuronal da damuwa na oxidative.

5. Kayan aiki don lakabin ƙwayar cuta Saboda tsarinsa irin na glucose-irinsa da iyawar shiga cikin glycolysis, 2-deoxy-d-glucose API za a iya amfani da shi azaman alamar rayuwa don nazarin yanayin rayuwa na motes da glucose-deduced a cikin sel da apkins.

A takaice,2-deoxy d glucose yana da ayyuka masu mahimmanci da yawa a cikin binciken kimiyya, ciki har da a matsayin mai hana glycolysis, mai haifar da autophagy, radiosensitizer, yiwuwar warkewa don cututtuka na neurodegenerative, da kayan aiki don lakabi na rayuwa. Aikace-aikacen sa suna da yuwuwar tasiri ga duka kimiyyar asali da magungunan asibiti.

Shigarwa & Jirgin Sama

Kashewa:1kg / tsare jakar; 5kg / kartani; 25kg / fiber drum; ko shiryawa kamar yadda kuke bukata.

gyare-gyare:

Alamar Musamman

Kayan kwalliya

Gyaran hoto

Lokacin jagora: A cikin kwanaki 3 na aiki bayan karɓar biya.

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Mu amfani

Kwarewar wadata: muna da Shekaru 13 na ƙwarewar ƙwararru;

Abokan ciniki a duk faɗin duniya: sayar da su zuwa ƙasashe fiye da 100;

Samar da samfuran iri-iri: samfuran an yi amfani da su ga duk manyan samfuran ƙasashen duniya a fagen magunguna, abubuwan abinci, kayan kwalliya, abinci mai gina jiki na dabba, da abinci mai aiki.

Farashin farashi: ƙananan MOQ tare da farashin gasa;

Takaddun shaida mai inganci: ISO; Halal; Kosher bokan

Sabis na tallace-tallace: Ƙwararrun ƙungiyar 7 * 24 hours sabis na abokin ciniki.

a ƙarshe

A taƙaice, a matsayin kwararre 2-Deoxy-D-glucose foda masana'anta, muna da fasahar ci gaba, fa'idar sikelin, mafi kyawun inganci, ƙwarewar samarwa mai wadata, da kyawawan ayyuka. Waɗannan fa'idodin za su sa ya fice a gasar kasuwa kuma ya sami ƙarin amincewa da goyan bayan abokin ciniki.

Idan kuna son ƙarin sani game da 2-DG ko kuna sha'awar siyan sa, zaku iya tuntuɓar mu a kowane lokaci. Za mu amsa muku da wuri-wuri bayan mun ga sakon.

bayanin tuntuɓar mu:

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